Article
ARLTS1 germline variants and the risk for breast, prostate, and colorectal cancer.
European journal of human genetics : EJHG - 1 Aug 2008
Siltanen Sanna, Syrjäkoski Kirsi, Fagerholm Rainer, Ikonen Tarja, Lipman Peter, Mallott Jacob, Holli Kaija, Tammela Teuvo L J, Järvinen Heikki J, Mecklin Jukka-Pekka, Aittomäki Kristiina, Blomqvist Carl, Bailey-Wilson Joan E, Nevanlinna Heli, Aaltonen Lauri A, Schleutker Johanna, Vahteristo Pia
Abstract excerpt
Recently, a nonsense alteration Trp149Stop in the ARLTS1 gene was found more frequently in familial cancer cases versus sporadic cancer patients and healthy controls. Here, the role of Trp149Stop or any other ARLTS1 germline variant was evaluated on breast, prostate, and colorectal cancer risk. The whole gene was screened for germline alterations in 855 familial cancer patients. The five observed variants were...
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