Article
ARLTS1, potential candidate gene in familial aggregation of hematological malignancies.
Bulletin du cancer - 1 Feb 2017
Hamadou Walid Sabri, Besbes Sawsen, Mani Rahma, Bourdon Violaine, Ben Youssef Yosra, Achour Béchir, Regaieg Haifa, Eisinger François, Mari Véronique, Gesta Paul, Dreyfus Hélène, Bonadona Valérie, Dugast Catherine, Zattara Hélène, Faivre Laurence, Noguchi Testsuro, Khélif Abderrahim, Sobol Hagay, Soua Zohra
Abstract excerpt
INTRODUCTION: Genetic predisposition to familial hematological malignancies was previously described through several epidemiological analyses, but the genetic basis remains unclear. The tumor-suppressor ARLTS1 gene was previously described in sporadic hematological malignancies and familial cancer context. METHODS: In this study, we sequence the ARLTS1 gene in 100 patients belonging to 88 independent Tunisian and...
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