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Article

Contribution of ARLTS1 Cys148Arg (T442C) variant with prostate cancer risk and ARLTS1 function in prostate cancer cells.

PloS one - 1 Jan 2011

Siltanen Sanna, Wahlfors Tiina, Schindler Martin, Saramäki Outi R, Mpindi John Patrick, Latonen Leena, Vessella Robert L, Tammela Teuvo L J, Kallioniemi Olli, Visakorpi Tapio, Schleutker Johanna

Abstract excerpt

ARLTS1 is a recently characterized tumor suppressor gene at 13q14.3, a region frequently deleted in both sporadic and hereditary prostate cancer (PCa). ARLTS1 variants, especially Cys148Arg (T442C), increase susceptibility to different cancers, including PCa. In this study the role of Cys148Arg substitution was investigated as a risk factor for PCa using both genetic and functional analysis. Cys148Arg genotypes...

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Identifiers

PMID: 22028916
DOI: 10.1371/journal.pone.0026595
PMCID: PMC3197657

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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