Article
Association of the ARLTS1 Cys148Arg variant with familial breast cancer risk.
International journal of cancer - 15 May 2006
Frank Bernd, Hemminki Kari, Meindl Alfons, Wappenschmidt Barbara, Klaes Rüdiger, Schmutzler Rita K, Untch Michael, Bugert Peter, Bartram Claus R, Burwinkel Barbara
Abstract excerpt
Recently, ARLTS1 (ADP-ribosylation factor-like tumor suppressor gene 1) has been identified as a tumor suppressor gene, playing a major role in apoptotic signaling. The ARLTS1 Trp149Stop mutation has been shown to predispose to general familial cancer and high-risk familial breast cancer (BC), provoking the attenuation of apoptotic function. We studied the impact of the ARLTS1 Pro131Leu and Cys148Arg variants on...
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