Article
Germline mutations of the MSR1 gene in prostate cancer families from Germany.
Human mutation - 1 Jan 2006
Maier Christiane, Vesovic Zorica, Bachmann Natascha, Herkommer Kathleen, Braun Anja K, Surowy Harald M, Assum Guenter, Paiss Thomas, Vogel Walther
Abstract excerpt
The MSR1 gene at 8p22 has been suggested as a candidate gene for hereditary prostate cancer because germline variants have been found to be associated with the disease. Aside from a single nonsense mutation (R293X) that was found repeatedly at low frequencies in several samples, little evidence has been gained by follow-up studies to confirm the gene's relevance for prostate cancer. Prompted by reasonable support...
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