Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus.

Biochemistry - 8 Apr 2008

Xu Hua, Sullivan Todd J, Sekiguchi Jun-ichiro, Kirikae Teruo, Ojima Iwao, Stratton Christopher F, Mao Weimin, Rock Fernando L, Alley M R K, Johnson Francis, Walker Stephen G, Tonge Peter J

Abstract excerpt

Approximately one-third of the world's population carries Staphylococcus aureus. The recent emergence of extreme drug resistant strains that are resistant to the "antibiotic of last resort", vancomycin, has caused a further increase in the pressing need to discover new drugs against this organism. The S. aureus enoyl reductase, saFabI, is a validated target for drug discovery. To drive the development of potent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enzyme Activation
Share to Enzyme Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catalysis

Share to Conserved Sequence

Share to Kinetics

Share to Molecular Structure

Share to Staphylococcus aureus

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 18335995
DOI: 10.1021/bi800023a
PMCID: PMC4397500

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus.PMID 18335995Read ↗

A Cholesterol Biosynthesis Inhibitor Blocks <i>Staphylococcus aureus</i> VirulenceSemantic proximity Read ↗

Staphylococcus aureus exploits lipoic acid salvage to combat host oxidative stressSemantic proximity Read ↗

YpdA, a putative bacillithiol disulfide reductase, contributes to cellular redox homeostasis and virulence in Staphylococcus aureusSemantic proximity Read ↗

The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations in Staphylococcus aureus Dihydropteroate SynthaseSemantic proximity Read ↗

Inhibition of Antibiotic-Resistant Staphylococcus aureus by the Broad-Spectrum Dihydrofolate Reductase Inhibitor RAB1Semantic proximity Read ↗

Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase.Semantic proximity Read ↗

Inhibiting Bacterial Fatty Acid SynthesisSemantic proximity Read ↗

Turnover-dependent covalent inactivation of Staphylococcus aureus coenzyme A-disulfide reductase by coenzyme A-mimetics: mechanistic and structural insights.Semantic proximity Read ↗

In Staphylococcus aureus , the acyl-CoA synthetase MbcS supports branched-chain fatty acid synthesis from carboxylic acid and aldehyde precursorsSemantic proximity Read ↗

An Efficient and Economical Assay to Screen for Triclosan Binding to FabI.Semantic proximity Read ↗

Structure and function of the dihydropteroate synthase from Staphylococcus aureus.Semantic proximity Read ↗

Understanding the link between antimicrobial properties of dietary olive phenolics and bacterial ATP synthase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.