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Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase.

Biochemistry - 31 May 2016

Neckles Carla, Pschibul Annica, Lai Cheng-Tsung, Hirschbeck Maria, Kuper Jochen, Davoodi Shabnam, Zou Junjie, Liu Nina, Pan Pan, Shah Sonam, Daryaee Fereidoon, Bommineni Gopal R, Lai Cristina, Simmerling Carlos, Kisker Caroline, Tonge Peter J

Abstract excerpt

The enoyl-ACP reductase (ENR) catalyzes the last reaction in the elongation cycle of the bacterial type II fatty acid biosynthesis (FAS-II) pathway. While the FabI ENR is a well-validated drug target in organisms such as Mycobacterium tuberculosis and Staphylococcus aureus, alternate ENR isoforms have been discovered in other pathogens, including the FabV enzyme that is the sole ENR in Yersinia pestis (ypFabV)....

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PMID: 27136302
DOI: 10.1021/acs.biochem.5b01301
PMCID: PMC4887296

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