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Article

Turnover-dependent covalent inactivation of Staphylococcus aureus coenzyme A-disulfide reductase by coenzyme A-mimetics: mechanistic and structural insights.

Biochemistry - 2 Oct 2012

Wallace Bret D, Edwards Jonathan S, Wallen Jamie R, Moolman Wessel J A, van der Westhuyzen Renier, Strauss Erick, Redinbo Matthew R, Claiborne Al

Abstract excerpt

Disruption of the unusual thiol-based redox homeostasis mechanisms in Staphylococcus aureus represents a unique opportunity to identify new metabolic processes and new targets for intervention. Targeting uncommon aspects of CoASH biosynthetic and redox functions in S. aureus, the antibiotic CJ-15,801 has recently been demonstrated to be an antimetabolite of the CoASH biosynthetic pathway in this organism;...

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PMID: 22954034
DOI: 10.1021/bi301026c
PMCID: PMC3506119

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