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Article

Increased CSF-BACE 1 activity is associated with ApoE-epsilon 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease.

Brain : a journal of neurology - 1 May 2008

Ewers Michael, Zhong Zhenyu, Bürger Katharina, Wallin Anders, Blennow Kaj, Teipel Stefan J, Shen Yong, Hampel Harald

Abstract excerpt

The Apolipoprotein (ApoE) epsilon 4 allele is a major genetic risk factor of Alzheimer's disease, and may affect the production of amyloid beta (A beta(1-42)). Recently, we have shown that beta-secretase (BACE 1) activity can be reliably detected within the brain and human CSF. Here, we have examined an association between the ApoE genotype and CSF-levels of BACE 1 activity in Alzheimer's disease and mild...

Topics

Aged
Aged, 80 and over
Alzheimer Disease
Amyloid Precursor Protein Secretases
Amyloid beta-Peptides
Apolipoproteins E
Aspartic Acid Endopeptidases
Biomarkers
Cognition Disorders
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Male

Middle Aged

Peptide Fragments

Source

Identifiers

PMID: 18334538
DOI: 10.1093/brain/awn034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18334538-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Increased CSF-BACE 1 activity is associated with ApoE-epsilon 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease.PMID 18334538Read ↗

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