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Article

Polymorphism in the BACE gene influences the risk for Alzheimer's disease.

Neuroreport - 1 Jul 2003

Kirschling Chartika M, Kölsch Heike, Frahnert Christine, Rao Marie Luise, Maier Wolfgang, Heun Reinhard

Abstract excerpt

Pathological characteristics of Alzheimer's disease (AD) are neurofibrillary tangles and amyloid-beta (Abeta) plaques. Abeta is generated by cleavage of the amyloid precursor protein by beta- and gamma-secretases. BACE (beta-site APP cleaving enzyme) was identified as the beta-secretase. Variations of the BACE gene might influence activity and function of the protein and, thus, might influence the pathogenesis of...

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Source

Identifiers

PMID: 12824768
DOI: 10.1097/00001756-200307010-00011

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Polymorphism in the BACE gene influences the risk for Alzheimer's disease.PMID 12824768Read ↗

Association studies using novel polymorphisms in BACE1 and BACE2.Semantic proximity Read ↗

Common BACE2 Polymorphisms are Associated with Altered Risk for Alzheimer’s Disease and CSF Amyloid Biomarkers in APOE ε4 Non-CarriersSemantic proximity Read ↗

Specific BACE1 genotypes provide additional risk for late-onset Alzheimer disease in APOE epsilon 4 carriers.Semantic proximity Read ↗

The association of beta-site APP cleaving enzyme (BACE) C786G polymorphism with Alzheimer's disease.Semantic proximity Read ↗

Mutations in the open reading frame of the beta-site APP cleaving enzyme (BACE) locus are not a common cause of Alzheimer's disease.Semantic proximity Read ↗

Relationship between the polymorphism in exon 5 of BACE1 gene and Alzheimer's disease.Semantic proximity Read ↗

Amyloid beta secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease.Semantic proximity Read ↗

Association study between Alzheimer's disease and genes involved in Abeta biosynthesis, aggregation and degradation: suggestive results with BACE1.Semantic proximity Read ↗

Association of BACE1 gene polymorphism with Alzheimer's disease in Asian populations: meta-analysis including Korean samples.Semantic proximity Read ↗

BACE1 gene promoter single-nucleotide polymorphisms in Alzheimer's disease.Semantic proximity Read ↗

Increased CSF-BACE 1 activity is associated with ApoE-epsilon 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease.Semantic proximity Read ↗

Meta-analysis of BACE1 gene rs638405 polymorphism and the risk of Alzheimer's disease in Caucasion and Asian population.Semantic proximity Read ↗

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