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Article

BACE1 levels by APOE genotype in non-demented and Alzheimer's post-mortem brains.

Current Alzheimer research - 1 Mar 2013

Decourt Boris, Gonzales Amanda, Beach Thomas G, Malek-Ahmadi Michael, Walker Aaron, Sue Lucia, Walker Douglas G, Sabbagh Marwan N

Abstract excerpt

The APOE genotype is a known susceptibility factor for Alzheimer's disease (AD). It is apparent that the presence of the APOE ε40 allele increases the risk for developing AD, lowers the age of onset in AD, and may influence the pathological burden seen in AD. In this study, we asked whether BACE1 levels differ by APOE genotype in the AD and non-demented (ND) brain. We isolated mid-frontal cortex (MFC) and...

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Source

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Identifiers

PMID: 23036023
DOI: 10.2174/1567205011310030010
PMCID: PMC4104947

Genes

APOE
BACE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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