Manganese binding to the prion protein.

Abstract excerpt

There is considerable evidence that the prion protein binds copper. However, there have also been suggestions that prion protein (PrP) binds manganese. We used isothermal titration calorimetry to identify the manganese binding sites in wild-type mouse PrP. The protein showed two manganese binding sites with affinities that would bind manganese at concentrations of 63 and 200 mum at pH 5.5. This indicates that PrP...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Binding Sites
• Share to Calorimetry
• Share to Circular Dichroism