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Article

Prion infection in cells is abolished by a mutated manganese transporter but shows no relation to zinc.

Molecular and cellular neurosciences - 1 Sept 2015

Pass Rachel, Frudd Karen, Barnett James P, Blindauer Claudia A, Brown David R

Abstract excerpt

The cellular prion protein has been identified as a metalloprotein that binds copper. There have been some suggestions that prion protein also influences zinc and manganese homeostasis. In this study we used a series of cell lines to study the levels of zinc and manganese under different conditions. We overexpressed either the prion protein or known transporters for zinc and manganese to determine relations...

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Source

Identifiers

PMID: 26253862
DOI: 10.1016/j.mcn.2015.08.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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