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Article

Consequences of manganese replacement of copper for prion protein function and proteinase resistance.

The EMBO journal - 15 Mar 2000

Brown D R, Hafiz F, Glasssmith L L, Wong B S, Jones I M, Clive C, Haswell S J

Abstract excerpt

The prion protein (PrP) binds copper and has antioxidant activity enhancing the survival of neurones in culture. The ability of the PrP to bind other cations was tested and it was found that only manganese could substitute for copper. Although initially manganese-loaded PrP exhibited similar structure and activity to copper-loaded PrP, after aging, manganese-loaded PrP became proteinase resistant and lost...

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Source

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Identifiers

PMID: 10716918
DOI: 10.1093/emboj/19.6.1180
PMCID: PMC305659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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