Activator-to-repressor conversion of T-box transcription factors by the Ripply family of Groucho/TLE-associated mediators.

Abstract excerpt

The T-box family of transcription factors, defined by a conserved DNA binding domain called the T-box, regulate various aspects of embryogenesis by activating and/or repressing downstream genes. In spite of the biological significance of the T-box proteins, how they regulate transcription remains to be elucidated. Here we show that the Groucho/TLE-associated protein Ripply converts T-box proteins from activators...

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