Article
Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice.
Development (Cambridge, England) - 1 Jan 2011
Okubo Tadashi, Kawamura Akinori, Takahashi Jun, Yagi Hisato, Morishima Masae, Matsuoka Rumiko, Takada Shinji
Abstract excerpt
The pharyngeal apparatus is a transient structure that gives rise to the thymus and the parathyroid glands and also contributes to the development of arteries and the cardiac outflow tract. A typical developmental disorder of the pharyngeal apparatus is the 22q11 deletion syndrome (22q11DS), for which Tbx1 is responsible. Here, we show that Ripply3 can modulate Tbx1 activity and plays a role in the development of...
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