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Article

Peptidyl-tRNA hydrolase is involved in lambda inhibition of host protein synthesis.

The EMBO journal - 1 Nov 1991

García-Villegas M R, De La Vega F M, Galindo J M, Segura M, Buckingham R H, Guarneros G

Abstract excerpt

Escherichia coli rap mutants do not support vegetative growth of bacteriophage lambda and die upon transcription of lambda DNA bar sites. Bacteria harbouring a pth(ts) mutation synthesize thermosensitive peptidyl-tRNA hydrolase (Pth) and die at 42 degrees C from a defect in protein synthesis. We present evidence that both rap and pth(ts) mutations affect the same gene: (i) peptidyl-tRNA hydrolase activity was...

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Identifiers

PMID: 1833189
DOI: 10.1002/j.1460-2075.1991.tb04919.x
PMCID: PMC453084

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Peptidyl-tRNA hydrolase is involved in lambda inhibition of host protein synthesis.PMID 1833189Read ↗

Regulation of protein synthesis by minigene expression.Semantic proximity Read ↗

Ribosomal RNA and peptidyl-tRNA hydrolase: a peptide chain termination model for lambda bar RNA inhibition.Semantic proximity Read ↗

A physiological connection between tmRNA and peptidyl-tRNA hydrolase functions in Escherichia coli.Semantic proximity Read ↗

Evidence of bar minigene expression and tRNA2Ile sequestration as peptidyl-tRNA2Ile during lambda bacteriophage development.Semantic proximity Read ↗

A short DNA sequence from lambda phage inhibits protein synthesis in Escherichia coli rap.Semantic proximity Read ↗

Inhibition of Escherichia coli protein synthesis by abortive translation of phage lambda minigenes.Semantic proximity Read ↗

Distribution of minigenes in the bacteriophage lambda chromosome.Semantic proximity Read ↗

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Increased bar minigene mRNA stability during cell growth inhibition.Semantic proximity Read ↗

The mutation that makes Escherichia coli resistant to lambda P gene-mediated host lethality is located within the DNA initiator Gene dnaA of the bacterium.Semantic proximity Read ↗

Shutdown in protein synthesis due to the expression of mini-genes in bacteria.Semantic proximity Read ↗

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