Peptidyl-tRNA hydrolase is involved in lambda inhibition of host protein synthesis.

doi:10.1002/j.1460-2075.1991.tb04919.x

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Article

Peptidyl-tRNA hydrolase is involved in lambda inhibition of host protein synthesis.

The EMBO journal - 1 Nov 1991

García-Villegas M R, De La Vega F M, Galindo J M, Segura M, Buckingham R H, Guarneros G

Abstract excerpt

Escherichia coli rap mutants do not support vegetative growth of bacteriophage lambda and die upon transcription of lambda DNA bar sites. Bacteria harbouring a pth(ts) mutation synthesize thermosensitive peptidyl-tRNA hydrolase (Pth) and die at 42 degrees C from a defect in protein synthesis. We present evidence that both rap and pth(ts) mutations affect the same gene: (i) peptidyl-tRNA hydrolase activity was...

Topics

Bacteriophage lambda
Base Sequence
Carboxylic Ester Hydrolases
Cloning, Molecular
Electrophoresis, Gel, Two-Dimensional
Escherichia coli
Genes, Bacterial
Genes, Lethal
Genes, Viral
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Open Reading Frames

Phenotype

Plasmids

Restriction Mapping

Transcription, Genetic

Virus Replication

Source

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Identifiers

PMID: 1833189
DOI: 10.1002/j.1460-2075.1991.tb04919.x
PMCID: PMC453084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1833189-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Peptidyl-tRNA hydrolase is involved in lambda inhibition of host protein synthesis.PMID 1833189Read ↗

Regulation of protein synthesis by minigene expression.Semantic proximity Read ↗

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Increased bar minigene mRNA stability during cell growth inhibition.Semantic proximity Read ↗

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