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Article

Shutdown in protein synthesis due to the expression of mini-genes in bacteria.

Journal of molecular biology - 27 Aug 1999

Dinçbas V, Heurgué-Hamard V, Buckingham R H, Karimi R, Ehrenberg M

Abstract excerpt

Mutants of Escherichia coli partially deficient in peptidyl-tRNA hydrolase are killed by the expression of certain very short open reading frames (mini-genes), encoded by the wild-type bar regions of phage lambda. According to the current hypothesis, protein synthesis is shut off, and the host cells die, after essential tRNA species become sequestered due to abnormal translation termination (drop-off) of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10452886
DOI: 10.1006/jmbi.1999.3028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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