Article
Excess of charged tRNALys maintains low levels of peptidyl-tRNA hydrolase in pth(Ts) mutants at a non-permissive temperature.
Nucleic acids research - 1 Jan 2006
Vivanco-Domínguez Serafin, Cruz-Vera Luis Rogelio, Guarneros Gabriel
Abstract excerpt
Cellular changes have been monitored during the suppression, mediated by the overproduction of tRNA(Lys), of thermosensitivity in Escherichia coli strain AA7852 carrying a mutation in peptidyl-tRNA hydrolase (Pth) encoded by the pth(Ts) gene. The presence in AA7852 cells of a plasmid bearing lysV gene helped to maintain low levels of the unstable Pth(Ts) protein and to preserve the viability of the mutant line at...
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