Article
Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells.
Developmental cell - 1 Mar 2008
Shen Yidong, Li Ning, Wu Shuang, Zhou Yizhuo, Shan Yongli, Zhang Qiangge, Ding Chong, Yuan Quan, Zhao Fukun, Zeng Rong, Zhu Xueliang
Abstract excerpt
Cdc42GAP promotes inactivation of Cdc42, a small GTPase whose activation at the leading edge by guanine nucleotide exchange factors is critical for cell migration. How Cdc42GAP is regulated to ensure proper levels of active Cdc42 is poorly understood. Here we show that Nudel, a cytoplasmic dynein regulator, competes with Cdc42 for binding Cdc42GAP. Consequently, Nudel can inhibit Cdc42GAP-mediated inactivation of...
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