Expression of human recombination activating genes (RAG1 and RAG2) in neoplastic lymphoid cells: correlation with cell differentiation and antigen receptor expression.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Expression of human recombination activating genes (RAG1 and RAG2) in neoplastic lymphoid cells: correlation with cell differentiation and antigen receptor expression.

Blood - 15 Oct 1991

Bories J C, Cayuela J M, Loiseau P, Sigaux F

Abstract excerpt

Regulation of V-(D)-J recombinations that occur in antigen receptor encoding genes remains poorly understood. Recently, two genes, RAG1 and RAG2, that are able to activate rearrangement of synthetic recombination substrates were cloned in mouse and a human gene homologous to RAG1 was described. To define the differentiation stages corresponding to RAG1 and RAG2 RNA expression, we have studied a large number of B-...

Topics

Alleles
B-Lymphocytes
Base Sequence
Burkitt Lymphoma
Cell Differentiation
Gene Expression Regulation, Leukemic
Genes, RAG-1
Humans
Leukemia-Lymphoma, Adult T-Cell
Lymphocyte Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Polymerase Chain Reaction

RNA, Messenger

Receptors, Antigen, T-Cell, alpha-beta

Receptors, Antigen, T-Cell, gamma-delta

Sequence Homology, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 1832998

Genes

RAG1
RAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1832998-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of human recombination activating genes (RAG1 and RAG2) in neoplastic lymphoid cells: correlation with cell differentiation and antigen receptor expression.PMID 1832998Read ↗

Early death and severe lymphopenia caused by ubiquitous expression of the Rag1 and Rag2 genes in mice.Semantic proximity Read ↗

Analysis of TCR, pT alpha, and RAG-1 in T-acute lymphoblastic leukemias improves understanding of early human T-lymphoid lineage commitment.Semantic proximity Read ↗

Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow.Semantic proximity Read ↗

RAG and RAG defects.Semantic proximity Read ↗

RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaksSemantic proximity Read ↗

Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.Semantic proximity Read ↗

Recombination activating genes (RAG) in lymphoma development.Semantic proximity Read ↗

A regulatory role for recombinase activating genes, RAG-1 and RAG-2, in T cell development.Semantic proximity Read ↗

Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-lymphocyte development.Semantic proximity Read ↗

Human common acute lymphoblastic leukemia-derived cell lines are competent to recombine their T-cell receptor delta/alpha regions along a hierarchically ordered pathway.Semantic proximity Read ↗

Basic helix-loop-helix proteins E2A and HEB induce immature T-cell receptor rearrangements in nonlymphoid cellsSemantic proximity Read ↗

High incidence and unique features of antigen receptor gene rearrangements in TEL-AML1-positive leukemias.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.