Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Early death and severe lymphopenia caused by ubiquitous expression of the Rag1 and Rag2 genes in mice.

European journal of immunology - 1 Dec 2001

Barreto V, Marques R, Demengeot J

Abstract excerpt

The recombination activating proteins (RAG1 and RAG2) are essential for V(D)J recombination of immunoglobulin chains. Expression of both genes is lymphocyte-specific and RAG levels are tightly regulated throughout lymphopoiesis and cell cycle. To assess the significance of this pattern of expression, we generated transgenic mice expressing the Rag genes both continuously throughout lymphocyte development and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, RAG-1
Share to Growth Disorders
Share to Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lymphocyte Count

Share to Lymphopenia

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to Transgenes

Source

Identifiers

PMID: 11745397
DOI: 10.1002/1521-4141(200112)31:12<3763::aid-immu3763>3.0.co;2-y

Genes

RAG1
RAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early death and severe lymphopenia caused by ubiquitous expression of the Rag1 and Rag2 genes in mice.PMID 11745397Read ↗

A regulatory role for recombinase activating genes, RAG-1 and RAG-2, in T cell development.Semantic proximity Read ↗

RAG deficiencies: Recent advances in disease pathogenesis and novel therapeutic approaches.Semantic proximity Read ↗

TCR selection and allelic exclusion in RAG transgenic mice that exhibit abnormal T cell localization in lymph nodes and lymphatics.Semantic proximity Read ↗

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement.Semantic proximity Read ↗

Omenn syndrome: a disorder of Rag1 and Rag2 genes.Semantic proximity Read ↗

Recent advances in understanding RAG deficienciesSemantic proximity Read ↗

RAG Deficiency: Two Genes, Many Diseases.Semantic proximity Read ↗

Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization.Semantic proximity Read ↗

RAG and RAG defects.Semantic proximity Read ↗

Hypomorphic Rag1 mutations alter the preimmune repertoire at early stages of lymphoid development.Semantic proximity Read ↗

RAG-dependent primary immunodeficiencies.Semantic proximity Read ↗

Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.