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Article

High incidence and unique features of antigen receptor gene rearrangements in TEL-AML1-positive leukemias.

Leukemia - 1 Jan 2004

Hübner S, Cazzaniga G, Flohr T, van der Velden V H J, Konrad M, Pötschger U, Basso G, Schrappe M, van Dongen J J M, Bartram C R, Biondi A, Panzer-Grümayer E R

Abstract excerpt

The t(12;21) translocation resulting in the TEL-AML1 gene fusion is found in 25% of childhood B-cell precursor (BCP) acute lymphoblastic leukemias (ALL). Since TEL-AML1 has been reported to induce cell cycle retardation and thus may influence somatic recombination, we analyzed 214 TEL-AML1-positive ALL by PCR for rearrangements of the immunoglobulin (Ig) and T-cell receptor (TCR) genes. As a control group, 174...

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Source

Identifiers

PMID: 14574333
DOI: 10.1038/sj.leu.2403182

Genes

IGH
IGK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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High incidence and unique features of antigen receptor gene rearrangements in TEL-AML1-positive leukemias.PMID 14574333Read ↗

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