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Article

[Chronic inflammation and gastric cancer development].

Nihon rinsho. Japanese journal of clinical medicine - 1 Oct 2012

Chiba Tsutomu, Marusawa Hiroyuki, Matsumoto Yuko, Takai Atsushi

Abstract excerpt

H. pylori-induced gastritis plays important roles in gastric cacrcinogenesis and cancer development is characterized by accumulation of various gene aberrations. Activation-induced cytidine deaminase (AID) is exclusively expressed in B lymphocytes and is essential for diversification of immunoglobulin genes. H. pylori-positive human gastritis mucosa ectopically express AID. H. pylori infection to gastric cells in...

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PMID: 23198547

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