Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A single nucleotide polymorphism in the carboxylesterase gene is associated with the responsiveness to imidapril medication and the promoter activity.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 Sept 2005

Geshi Eiichi, Kimura Tomomi, Yoshimura Mika, Suzuki Hiroshi, Koba Shinji, Sakai Tetsuo, Saito Tsukasa, Koga Atsuro, Muramatsu Masaaki, Katagiri Takashi

Abstract excerpt

Imidapril is an angiotensin-converting enzyme inhibitor that is widely used in treating hypertension, although the responses vary among individuals. We investigated whether a single nucleotide polymorphism at position -816 of the carboxylesterase 1 (CES1) gene, which activates imidapril in the liver, is involved in the responsiveness to imidapril medication. A total of 105 Japanese hypertensives with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Angiotensin-Converting Enzyme Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antihypertensive Agents

Share to Carboxylesterase

Share to Genotype

Share to Hypertension

Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 16419644
DOI: 10.1291/hypres.28.719

Genes

CES1
DBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A single nucleotide polymorphism in the carboxylesterase gene is associated with the responsiveness to imidapril medication and the promoter activity.PMID 16419644Read ↗

Functional polymorphisms in carboxylesterase1A2 (CES1A2) gene involves specific protein 1 (Sp1) binding sites.Semantic proximity Read ↗

CES1P1 variant -816A>C is not associated with hepatic carboxylesterase 1 expression and activity or antihypertensive effect of trandolapril.Semantic proximity Read ↗

CES1 genetic variation affects the activation of angiotensin-converting enzyme inhibitors.Semantic proximity Read ↗

Pharmacogenetic study of CES1 gene and enalapril efficacy.Semantic proximity Read ↗

Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers.Semantic proximity Read ↗

A Comprehensive Functional Assessment of Carboxylesterase 1 Nonsynonymous Polymorphisms.Semantic proximity Read ↗

Major implications of single nucleotide polymorphisms in human carboxylesterase 1 on substrate bioavailability.Semantic proximity Read ↗

Identification of regulatory variants of carboxylesterase 1 (CES1): A proof-of-concept study for the application of the Allele-Specific Protein Expression (ASPE) assay in identifying cis-acting regulatory genetic polymorphisms.Semantic proximity Read ↗

The Influence of Structural Variants of the CES1 Gene on the Pharmacokinetics of Enalapril, Presumably Due to Linkage Disequilibrium with the Intronic rs2244613.Semantic proximity Read ↗

Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril.Semantic proximity Read ↗

Effect of CES1 genetic variation on enalapril steady-state pharmacokinetics and pharmacodynamics in healthy subjects.Semantic proximity Read ↗

Mutation-sensitive molecular switch method to detect CES1A2 mutation in the Chinese Han and Yao populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.