Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Self-association of the Gal4 inhibitor protein Gal80 is impaired by Gal3: evidence for a new mechanism in the GAL gene switch.

Molecular and cellular biology - 1 Sept 2013

Egriboz Onur, Goswami Sudip, Tao Xiaorong, Dotts Kathleen, Schaeffer Christie, Pilauri Vepkhia, Hopper James E

Abstract excerpt

The DNA-binding transcriptional activator Gal4 and its regulators Gal80 and Gal3 constitute a galactose-responsive switch for the GAL genes of Saccharomyces cerevisiae. Gal4 binds to GAL gene UASGAL (upstream activation sequence in GAL gene promoter) sites as a dimer via its N-terminal domain and activates transcription via a C-terminal transcription activation domain (AD). In the absence of galactose, a Gal80...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding, Competitive
Share to Galactose

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Fungal

Share to Protein Interaction Domains and Motifs

Share to Protein Multimerization

Share to Protein Structure, Quaternary

Share to Repressor Proteins

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 23858060
DOI: 10.1128/MCB.00646-12
PMCID: PMC3753875

Genes

GAL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Self-association of the Gal4 inhibitor protein Gal80 is impaired by Gal3: evidence for a new mechanism in the GAL gene switch.PMID 23858060Read ↗

Gal80 dimerization and the yeast GAL gene switch.Semantic proximity Read ↗

Nondissociation of GAL4 and GAL80 in vivo after galactose induction.Semantic proximity Read ↗

GAL4 mutations that separate the transcriptional activation and GAL80-interactive functions of the yeast GAL4 protein.Semantic proximity Read ↗

Intragenic suppression of Gal3C interaction with Gal80 in the Saccharomyces cerevisiae GAL gene switch.Semantic proximity Read ↗

Genetic evidence for sites of interaction between the Gal3 and Gal80 proteins of the Saccharomyces cerevisiae GAL gene switch.Semantic proximity Read ↗

Galactose-dependent reversible interaction of Gal3p with Gal80p in the induction pathway of Gal4p-activated genes of Saccharomyces cerevisiae.Semantic proximity Read ↗

Purification and characterization of the yeast negative regulatory protein GAL80.Semantic proximity Read ↗

Novel Gal3 proteins showing altered Gal80p binding cause constitutive transcription of Gal4p-activated genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

Replacement of a conserved tyrosine by tryptophan in Gal3p of Saccharomyces cerevisiae reduces constitutive activity: implications for signal transduction in the GAL regulon.Semantic proximity Read ↗

The Gal3p transducer of the GAL regulon interacts with the Gal80p repressor in its ligand-induced closed conformation.Semantic proximity Read ↗

Activation domain-dependent monoubiquitylation of Gal4 protein is essential for promoter binding in vivo.Semantic proximity Read ↗

Galactose induction in yeast involves association of Gal80p with Gal1p or Gal3p.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.