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Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice.

Neuro-degenerative diseases - 1 Jan 2008

Eckert Anne, Hauptmann Susanne, Scherping Isabel, Rhein Virginie, Müller-Spahn Franz, Götz Jürgen, Müller Walter E

Abstract excerpt

BACKGROUND: Mitochondrial dysfunction has been identified in neurodegenerative disorders including Alzheimer's disease, where accumulation of beta-amyloid (Abeta) and oxidative stress seem to play central roles in the pathogenesis, by probably directly leading to mitochondrial dysfunction. OBJECTIVE: In order to study the in vivo effect of Abeta load during aging, we evaluated the mitochondrial function of brain...

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PMID: 18322377
DOI: 10.1159/000113689

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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