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Article

Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice.

Neuro-degenerative diseases - 1 Jan 2008

Eckert Anne, Hauptmann Susanne, Scherping Isabel, Rhein Virginie, Müller-Spahn Franz, Götz Jürgen, Müller Walter E

Abstract excerpt

BACKGROUND: Mitochondrial dysfunction has been identified in neurodegenerative disorders including Alzheimer's disease, where accumulation of beta-amyloid (Abeta) and oxidative stress seem to play central roles in the pathogenesis, by probably directly leading to mitochondrial dysfunction. OBJECT...

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Identifiers

PMID: 18322377
DOI: 10.1159/000113689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18322377-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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