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Article

Dissecting toxicity of tau and beta-amyloid.

Neuro-degenerative diseases - 1 Jan 2010

Götz Jürgen, Lim Yun-An, Ke Yazi D, Eckert Anne, Ittner Lars M

Abstract excerpt

BACKGROUND: How beta-amyloid (Abeta) and tau exert toxicity in Alzheimer's disease is only partly understood. Major questions include (1) which aggregation state of Abeta confers toxicity, (2) do amyloidogenic proteins have similar mechanisms of toxicity, and (3) does soluble tau interfere with cellular functions? METHODS: To determine Abeta toxicity in P301L mutant tau transgenic mice, mitochondrial function was...

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PMID: 20160450
DOI: 10.1159/000283475

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