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Article

Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease.

Molecular neurodegeneration - 2 May 2014

Kukreja Lokesh, Kujoth Gregory C, Prolla Tomas A, Van Leuven Fred, Vassar Robert

Abstract excerpt

BACKGROUND: The role of mitochondrial dysfunction has long been implicated in age-related brain pathology, including Alzheimer's disease (AD). However, the mechanism by which mitochondrial dysfunction may cause neurodegeneration in AD is unclear. To model mitochondrial dysfunction in vivo, we utilized mice that harbor a knockin mutation that inactivates the proofreading function of mitochondrial DNA polymerase γ...

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Source

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Identifiers

PMID: 24885175
DOI: 10.1186/1750-1326-9-16
PMCID: PMC4028006

Genes

APP
BACE1
IDE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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