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Characterization of ATP Alternations in an Alzheimer's Disease Transgenic Mouse Model

22 Jan 2015

Abstract excerpt

Mitochondrial impairment as evidenced by decline in adenosine 5'-triphosphate (ATP) is associated with oxidative stress in Alzheimer's disease neuropathology and suggests that mitochondria may fail to maintain cellular energy, through reduced ATP production in neurons. To gain insights into the ATP characteristics of Alzheimer's disease transgenic (Tg) mice, we investigated ATP contents in the brain and whole...

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PMID: 25261448
DOI: 10.3233/jad-141890

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