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Article

Altering DNA Repair to Improve Radiation Therapy: Specific and Multiple Pathway Targeting

10 Oct 2019

Abstract excerpt

Radiation therapy (RT) is widely used in cancer care strategies. Its effectiveness relies mainly on its ability to cause lethal damage to the DNA of cancer cells. However, some cancers have shown to be particularly radioresistant partly because of efficient and redundant DNA repair capacities. Therefore, RT efficacy might be enhanced by using drugs that can disrupt cancer cells' DNA repair machinery. Here we...

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PMID: 31649878
DOI: 10.3389/fonc.2019.01009

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