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Article

Iron-induced oligomerization of yeast frataxin homologue Yfh1 is dispensable in vivo.

EMBO reports - 1 Nov 2004

Aloria Kerman, Schilke Brenda, Andrew Amy, Craig Elizabeth A

Abstract excerpt

The neurodegenerative disease Friedreich's ataxia is caused by reduced levels of frataxin, a mitochondrial matrix protein. The in vivo role of frataxin is under debate. Frataxin, as well as its yeast homologue Yfh1, binds multiple iron atoms as an oligomer and has been proposed to function as a crucial iron-storage protein. We identified a mutant Yfh1 defective in iron-induced oligomerization. This mutant protein...

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Identifiers

PMID: 15472712
DOI: 10.1038/sj.embor.7400272
PMCID: PMC1299167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Iron-induced oligomerization of yeast frataxin homologue Yfh1 is dispensable in vivo.PMID 15472712Read ↗

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