Article
The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins.
Human molecular genetics - 15 Aug 2002
Mühlenhoff Ulrich, Richhardt Nadine, Ristow Michael, Kispal Gyula, Lill Roland
Abstract excerpt
The mitochondrial matrix protein frataxin is depleted in patients with Friedreich's ataxia, the most common autosomal recessive ataxia. While frataxin is important for intracellular iron homeostasis, its exact cellular role is unknown. Deletion of the yeast frataxin homolog YFH1 yields mutants ((Delta)yfh1) that, depending on the genetic background, display various degrees of phenotypic defects. This renders it...
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