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Article

Haploinsufficiency for either one of the type-II regulatory subunits of protein kinase A improves the bone phenotype of Prkar1a+/- mice.

Human molecular genetics - 1 Nov 2015

Liu Sisi, Saloustros Emmanouil, Mertz Edward L, Tsang Kitman, Starost Matthew F, Salpea Paraskevi, Faucz Fabio R, Szarek Eva, Nesterova Maria, Leikin Sergey, Stratakis Constantine A

Abstract excerpt

Carney Complex (CNC), a human genetic syndrome predisposing to multiple neoplasias, is associated with bone lesions such as osteochondromyxomas (OMX). The most frequent cause for CNC is PRKAR1A deficiency; PRKAR1A codes for type-I regulatory subunit of protein kinase A (PKA). Prkar1a(+/-) mice developed OMX, fibrous dysplasia-like lesions (FDL) and other tumors. Tumor tissues in these animals had increased PKA...

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Share to Antigens, Differentiation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cyclic AMP-Dependent Protein Kinase RIalpha Subunit

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Source

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Identifiers

PMID: 26246497
DOI: 10.1093/hmg/ddv320
PMCID: PMC4599668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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