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Article

Inherited disposition to cardiac myxoma development.

Nature reviews. Cancer - 1 Feb 2006

Wilkes David, Charitakis Konstantinos, Basson Craig T

Abstract excerpt

Carney complex is a genetic condition in which affected individuals develop benign tumours in various tissues, including the heart. Most individuals with Carney complex have a mutation in the PRKAR1A gene, which encodes the regulatory R1alpha subunit of protein kinase A - a significant component of the cyclic-AMP signalling pathway. Genetically engineered mutant Prkar1a mouse models show an increased propensity...

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PMID: 16491075
DOI: 10.1038/nrc1798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inherited disposition to cardiac myxoma development.PMID 16491075Read ↗

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Use of mouse models to understand the molecular basis of tissue-specific tumorigenesis in the Carney complex.Semantic proximity Read ↗

Differential role of PKA catalytic subunits in mediating phenotypes caused by knockout of the Carney complex gene Prkar1a.Semantic proximity Read ↗

A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues.Semantic proximity Read ↗

Mutations in the protein kinase A R1α regulatory subunit cause familial cardiac myxomas and Carney complexSemantic proximity Read ↗

Heart-Specific Ablation of <i>Prkar1a</i> Causes Failure of Heart Development and MyxomagenesisSemantic proximity Read ↗

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