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Article

Influence of CYP2C1918 and CYP2C1919 alleles on omeprazole 5-hydroxylation: in vitro functional analysis of recombinant enzymes expressed in Saccharomyces cerevisiae.

Basic & clinical pharmacology & toxicology - 1 Apr 2008

Hanioka Nobumitsu, Tsuneto Yumi, Saito Yoshiro, Maekawa Keiko, Sawada Jun-Ichi, Narimatsu Shizuo

Abstract excerpt

Omeprazole is one of the most widely used proton pump inhibitors for the treatment of gastric acid-related disorders. The major metabolic pathway of omeprazole is 5-hydroxylation, which is catalysed by CYP2C19. In this study, the effect of CYP2C19*18 and CYP2C19*19 alleles on omeprazole 5-hydroxy...

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Source

Identifiers

PMID: 18312490
DOI: 10.1111/j.1742-7843.2008.00222.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18312490-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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