Article

Chronic Aryl Hydrocarbon Receptor Activity Phenocopies Smoking-induced Skeletal Muscle Impairment

2021-05-05

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> COPD patients exhibit skeletal muscle atrophy, denervation, and reduced mitochondrial oxidative capacity. Whilst chronic tobacco smoke exposure is implicated in COPD muscle impairment, the mechanisms involved are ambiguous. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that activates detoxifying pathways with numerous exogenous ligands, inclu...

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Literature Corpus work: 971dab04-d0ef-59d7-b587-e973171d3152
DOI: 10.1101/2021.05.05.441943

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