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Article

Understanding synergy in genetic interactions.

Trends in genetics : TIG - 1 Aug 2009

Pérez-Pérez José Manuel, Candela Héctor, Micol José Luis

Abstract excerpt

Synergy occurs when the contribution of two mutations to the phenotype of a double mutant exceeds the expectations from the additive effects of the individual mutations. The molecular characterization of genes involved in synergistic interactions has revealed that synergy mainly results from mutations in functionally related genes. Recent research in Arabidopsis thaliana has advanced our understanding of the...

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PMID: 19665253
DOI: 10.1016/j.tig.2009.06.004

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