Article
Increased monocyte adhesion by endothelial expression of VCAM-1 missense variation in vitro.
Atherosclerosis - 1 Oct 2013
Schmitz Boris, Vischer Peter, Brand Eva, Schmidt-Petersen Klaus, Korb-Pap Adelheid, Guske Katrin, Nedele Johanna, Schelleckes Michael, Hillen Jan, Rötrige Alois, Simmet Thomas, Paul Martin, Cambien François, Brand Stefan-Martin
Abstract excerpt
OBJECTIVE: In whole genome and single gene analyses, genetic variation at the vascular cell adhesion molecule-1 (VCAM-1) locus has been associated with inflammatory disease and stroke in sickle cell anaemia. In the current work, we investigated the functional impact of VCAM-1 missense variants and their effect on cell-cell adhesion. METHODS AND RESULTS: To determine the functional in vitro relevance of five...
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