Phenotypic differences of human neutrophils of carriers of the PSGL-1 A and B-allele in binding to immobilised P-selectin under flow conditions.

doi:10.1016/j.thromres.2010.11.010

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Article

Phenotypic differences of human neutrophils of carriers of the PSGL-1 A and B-allele in binding to immobilised P-selectin under flow conditions.

Thrombosis research - 1 Feb 2011

Meyer dos Santos Sascha, Klinkhardt Ute, Lang Katharina, Parisius Jeannine, Kuczka Karina, Harder Sebastian

Abstract excerpt

P-selectin glycoprotein ligand-1 (PSGL-1) interacts with P-selectin expressed on endothelial cells and platelets. PSGL-1 extracellular mucin-like domain displays a variable number of tandem repeats (VNTRs) polymorphism. The wildtype consists of 16 decameric repeats (designated A isoforms) and variants with 15 (B allele) and 14 (C allele) repeats that are assumed to be associated with reduced risk of vascular...

Topics

Adult
Alleles
Amino Acid Sequence
Animals
CHO Cells
Cell Adhesion
Cricetinae
Cricetulus
Female
Flow Cytometry
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Membrane Glycoproteins

Minisatellite Repeats

Molecular Sequence Data

Neutrophils

P-Selectin

Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 21144558
DOI: 10.1016/j.thromres.2010.11.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21144558-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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