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Article

On-chip phenotypic analysis of inflammatory monocytes in atherogenesis and myocardial infarction.

Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 2013

Foster Greg A, Gower R Michael, Stanhope Kimber L, Havel Peter J, Simon Scott I, Armstrong Ehrin J

Abstract excerpt

Monocyte recruitment to inflamed arterial endothelium initiates plaque formation and drives progression of atherosclerosis. Three distinct monocyte subsets are detected in circulation (CD14(++)CD16(-), CD14(++)CD16(+), and CD14(+)CD16(++)), and each may play distinct roles during atherogenesis and myocardial infarction. We studied a range of subjects that included otherwise healthy patients with elevated serum...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23918401
DOI: 10.1073/pnas.1300651110
PMCID: PMC3752270

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