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4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians.

Pharmacogenetics and genomics - 1 Mar 2008

Diczfalusy Ulf, Miura Jun, Roh Hyung-Keun, Mirghani Rajaa A, Sayi Jane, Larsson Hanna, Bodin Karl G, Allqvist Annika, Jande Mary, Kim Jong-Wook, Aklillu Eleni, Gustafsson Lars L, Bertilsson Leif

Abstract excerpt

OBJECTIVES: To study the potential endogenous marker of CYP3A activity, 4beta-hydroxycholesterol, and its relation to sex and the CYP3A5 geno/haplotypes and compare with CYP3A4/5 catalyzed 3-hydroxylation of quinine in the three major races. METHODS: The plasma concentration of 4beta-hydroxycholesterol was measured in healthy Tanzanians (n=138), Swedes (n=161) and Koreans (n=149) by gas chromatography-mass...

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PMID: 18300941
DOI: 10.1097/FPC.0b013e3282f50ee9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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