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Article

Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans.

Therapeutic drug monitoring - 1 Jun 2010

Mukonzo Jackson K, Waako Paul, Ogwal-Okeng Jasper, Gustafsson Lars L, Aklillu Eleni

Abstract excerpt

Quinine is one of the most effective antimalarial drugs, although its clinical use is limited as a result of its narrow safety margin. Quinine is a substrate of the polymorphic p-glycoprotein and CYP3A4/3A5. This study aimed to examine the effects of genetic variations in ABCB1 and CYP3A5 genes, sex, demographic, and biochemical variables (serum albumin, creatinine, alanine aminotransferase and albumin) on...

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Identifiers

PMID: 20357698
DOI: 10.1097/FTD.0b013e3181da79d6

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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