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Article

Susceptibility of pRb-deficient epidermis to chemical skin carcinogenesis is dependent on the p107 allele dosage.

Molecular carcinogenesis - 1 Nov 2008

Santos Mirentxu, Ruiz Sergio, Lara M Fernanda, Segrelles Carmen, Moral Marta, Martínez-Cruz Ana Belén, Ballestín Claudio, Lorz Corina, García-Escudero Ramón, Paramio Jesús M

Abstract excerpt

Functional inactivation of the pRb-dependent pathway is a general feature of human cancer. However, only a reduced spectrum of tumors displays inactivation of the Rb gene. This can be attributed, at least partially, to the possible overlapping functions carried out by the related retinoblastoma family members p107 and p130. We observed that loss of pRb in epidermis, using the Cre/LoxP technology, results in...

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Identifiers

PMID: 18300254
DOI: 10.1002/mc.20426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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