Article
Spontaneous squamous cell carcinoma induced by the somatic inactivation of retinoblastoma and Trp53 tumor suppressors.
Cancer research - 1 Feb 2008
Martínez-Cruz Ana Belén, Santos Mirentxu, Lara M Fernanda, Segrelles Carmen, Ruiz Sergio, Moral Marta, Lorz Corina, García-Escudero Ramón, Paramio Jesús M
Abstract excerpt
Squamous cell carcinomas (SCC) represent the most aggressive type of nonmelanoma skin cancer. Although little is known about the causal alterations of SCCs, in organ-transplanted patients the E7 and E6 oncogenes of human papillomavirus, targeting the p53- and pRb-dependent pathways, have been widely involved. Here, we report the functional consequences of the simultaneous elimination of Trp53 and retinoblastoma...
Topics
- Animals
- Carcinoma, Squamous Cell
- Cell Transformation, Neoplastic
- Gene Expression Regulation, Neoplastic
- Gene Silencing
- Genes, Retinoblastoma
- Genetic Predisposition to Disease
- Hair Follicle
- Immunohistochemistry
- MAP Kinase Signaling System
- Mice
- Neovascularization, Pathologic