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Article

Distinct and nonoverlapping roles for pRB and cyclin D:cyclin-dependent kinases 4/6 activity in melanocyte survival.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2003

Yu Benjamin D, Becker-Hapak Michelle, Snyder Eric L, Vooijs Marc, Denicourt Catherine, Dowdy Steven F

Abstract excerpt

Deregulation of the p16INK4a-cyclin D:cyclin-dependent kinases (cdk) 4/6-retinoblastoma (pRB) pathway is a common paradigm in the oncogenic transformation of human cells and suggests that this pathway functions linearly in malignant transformation. However, it is not understood why p16INK4a and cyclin D:cdk4/6 mutations are disproportionately more common than the rare genetic event of RB inactivation in human...

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PMID: 14630948
DOI: 10.1073/pnas.2431391100
PMCID: PMC299840

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