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Article

Genetic circuitry modulating notch signals through endosomal trafficking.

Methods in enzymology - 1 Jan 2014

Hori Kazuya, Sen Anindya, Artavanis-Tsakonas Spyros

Abstract excerpt

Genetic modifier screens offer a powerful, indeed a uniquely powerful tool for the analysis and identification of elements capable of modulating specific cellular functions in development. Here, we describe the methodology that allowed us to explore the genetic circuitry that affects a Notch mutant phenotype caused by the abnormal endosomal trafficking of the Notch receptor. Endosomal trafficking events are...

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PMID: 24359960
DOI: 10.1016/B978-0-12-397926-1.00016-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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