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Article

Association between variations in the TLR4 gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol.

BMC medical genetics - 25 Feb 2008

Kolz Melanie, Baumert Jens, Müller Martina, Khuseyinova Natalie, Klopp Norman, Thorand Barbara, Meisinger Christine, Herder Christian, Koenig Wolfgang, Illig Thomas

Abstract excerpt

BACKGROUND: Toll-like receptor 4 (TLR4), the signaling receptor for lipopolysaccharides, is an important member of the innate immunity system. Since several studies have suggested that type 2 diabetes might be associated with changes in the innate immune response, we sought to investigate the association between genetic variants in the TLR4 gene and incident type 2 diabetes. METHODS: A case-cohort study was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18298826
DOI: 10.1186/1471-2350-9-9
PMCID: PMC2292153

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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