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Article

TLR4 gene polymorphisms: evidence for protection against type 2 diabetes but not for diabetes-associated ischaemic heart disease.

European journal of endocrinology - 1 Aug 2011

Manolakis A C, Kapsoritakis A N, Tiaka E K, Sidiropoulos A, Gerovassili A, Satra M, Vamvakopoulou D, Tsiopoulos F, Papanas N, Skoularigis I, Potamianos S P, Vamvakopoulos N

Abstract excerpt

OBJECTIVE: Several factors either predisposing or protecting from the onset of diabetes mellitus type 2 (DM2) have been proposed. Two specific polymorphisms of toll-like receptor 4 (TLR4; Asp299Gly and Thr399Ile) have recently been identified either as candidate protector genes against DM2 and associated neuropathy or risk alleles for the manifestation of diabetic retinopathy. The impact of these alleles on the...

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Identifiers

PMID: 21628510
DOI: 10.1530/EJE-11-0280

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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