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Article

Position effect variegation and epigenetic modification of a transgene in a pig model.

Genetics and molecular research : GMR - 16 Feb 2012

Yin Z, Kong Q R, Zhao Z P, Wu M L, Mu Y S, Hu K, Liu Z H

Abstract excerpt

Sequences proximal to transgene integration sites are able to regulate transgene expression, resulting in complex position effect variegation. Position effect variegation can cause differences in epigenetic modifications, such as DNA methylation and histone acetylation. However, it is not known which factor, position effect or epigenetic modification, plays a more important role in the regulation of...

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PMID: 22370938
DOI: 10.4238/2012.February.16.1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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